For recent ingestions (within a few hours), aggressive decontamination with emesis (induced vomiting) and repeated doses of activated charcoal are recommended. Prolonged hospitalization and frequent laboratory monitoring are required. This is one of the most challenging poisoning cases to treat. There is no antidote for cholecalciferol mouse and rat poison and. While the renal system is often most acutely affected, eventually the cardiac, pulmonary GI and CNS systems may be as well.Ġ-24 hours: Increased thirst and urination, hypercalcemia, hyperphosphatemiaġ2-48 hours: Anorexia, vomiting, weakness, lethargy, melena (black stool with digested blood)ģ-5 days: Depression, frank bloody diarrhea, hematuria, prominent bradycardia, death Signs typically begin 12-24 hours after ingestion and may be non-specific at the onset. Human vitamin D3 supplements taken at high enough doses are also toxic via this same mechanism. Even though this is a vitamin, it is toxic to dogs, cats, and children as well as rodents. This can progress to life-threatening disease.
Cholecalciferol, or activated vitamin D3, causes a life-threateningly high calcium and phosphorus level in the body, resulting in severe, acute kidney failure, cardiovascular abnormalities, and tissue mineralization. This is one of the most dangerous mouse and rat poisons on the market.
